Amyloidosis is a group of diseases in which amyloid-a protein-like substance-builds up in the organs and tissues. The buildup may happen systemically (throughout the body) or locally (in one tissue).

  1. Heart disease and irregular heart beat
  2. Kidney disorders, including kidney failure
  3. Gastrointestinal (GI) disorders, such as perforation (hole), bleeding, slow movement of matter through the GI tract, and blockage
  4. Enlarged liver
  5. Diminished function of the spleen
  6. Diminished function of the adrenal and other endocrine glands
  7. Problems in transmitting nerve signals, which could lead to impotence, gastrointestinal problems, and orthostatic hypotension (low blood pressure upon standing)
  8. Carpal tunnel syndrome (compression and irritation of the median nerve in the wrist)
  9. Skin conditions, such as growths, color changes, purpura (bleeding into the skin) around the eyes, and easy bruising
  10. Enlarged tongue, sometimes with swelling under the jaw, breathing difficulties, and sleep apnea
  11. Lung problems
  12. Swelling of the shoulder joints (may look like shoulder pads under the skin)
  13. Susceptibility to bleeding problems