Wegener's granulomatosis is an uncommon disease defined by inflammation of the blood vessels (vasculitis), kidneys (glomerulonephritis) and the upper and lower respiratory tract (sinuses, nose, trachea, and lungs).
- The initial symptoms of Wegener's granulomatosis are often vague or nonspecific and frequently include upper respiratory tract symptoms, joint pains, weakness, and fatigue.
- The most common sign of Wegener’s granulomatosis is involvement of the upper respiratory tract, which occurs in nearly all patients.
- Symptoms include sinus pain, discolored or bloody nasal drainage and, occasionally, nasal ulcerations.
- A common manifestation of the disease is persistent rhinorrhea ("runny nose") or other cold symptoms that do not respond to standard treatment or that become progressively worse.