Wegener's granulomatosis is an uncommon disease defined by inflammation of the blood vessels (vasculitis), kidneys (glomerulonephritis) and the upper and lower respiratory tract (sinuses, nose, trachea, and lungs).

  1. The initial symptoms of Wegener's granulomatosis are often vague or nonspecific and frequently include upper respiratory tract symptoms, joint pains, weakness, and fatigue.
  2. The most common sign of Wegener’s granulomatosis is involvement of the upper respiratory tract, which occurs in nearly all patients.
  3. Symptoms include sinus pain, discolored or bloody nasal drainage and, occasionally, nasal ulcerations.
  4. A common manifestation of the disease is persistent rhinorrhea ("runny nose") or other cold symptoms that do not respond to standard treatment or that become progressively worse.