1. Two medications currently are used to treat acromegaly. These drugs reduce both GH secretion and tumor size.
  2. Medical therapy is sometimes used to shrink large tumors before surgery. Bromocriptine (ParlodelĀ®) in divided doses of about 20 mg daily reduces GH secretion from some pituitary tumors.
  3. Side effects include gastrointestinal upset, nausea, vomiting, light-headedness when standing, and nasal congestion. These side effects can be reduced or eliminated if medication is started at a very low dose at bedtime, taken with food, and gradually increased to the full therapeutic dose.
  4. Radiation therapy has been used both as a primary treatment and combined with surgery or drugs.
  5. It is usually reserved for patients who have tumor remaining after surgery. These patients often also receive medication to lower GH levels.
  6. This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement.