People with amyloidosis affecting the heart are extremely sensitive to certain medicines. Digoxin may cause fatal irregular heartbeat. Calcium-channel blockers may worsen congestive heart failure. Diuretics and vasodilators may cause life-threatening low blood pressure.

  1. Under select circumstances, certain drug combinations, many of which are under investigation, have been used to treat primary amyloidosis.
  2. For amyloidosis related to kidney failure, researchers are studying other treatments, such as using new dialysis systems and adding antioxidants to the dialysis fluid; antioxidants may help rid the body of unstable compounds known as free radicals.