As soon as your doctor suspects that you have plague, you'll need to be admitted to an isolation room in a hospital. There, you'll receive powerful antibiotics directly into your veins (intravenously) or your muscles (intramuscularly) for at least 10 days.

  1. Streptomycin and gentamicin are the most effective drugs against plague.
  2. Other alternatives include intravenous doxycycline (Vibramycin), ciprofloxacin (Cipro) and chloramphenicol (Chloromycetin).
  3. If you have serious complications, such as bleeding abnormalities, organ failure and respiratory distress, then respiratory support, intravenous fluids and oxygen may be necessary.
  4. Even if you don't have signs or symptoms, you'll need treatment with preventive, oral antibiotics for seven days after direct exposure to a person with pneumonic plague.