Treatment may be useful in several ways. Proper advice will ensure the elimination of potentially harmful drugs, foods, or toxins.
- If the patient is deficient in vitamin D, then this should be corrected. The thyroid function should be tested and, if low, treated with a thyroid hormone.
- Symptoms may be successfully relieved. Itching is often reduced by using cholestryramine and rifampin. Salt restriction may be effective in reducing fluid accumulation.
- The diet should be well-balanced. Corticosteroids have been found ineffective in most patients. The FDA has approved only URSO 250 (manufactured by Axcan Scandipharm) for use in patients with PBC. The recommended dose is 13-15 mg/kg once a day.
- Physicians who treat PNC patients often prescribe other ursodiol products off-label. These products include Actigall (manufactured by Novartis) and various generic formulations.