When symptomatic, those symptoms directly related to elevated IgM levels are treated by plasmapheresis alone to remove the excess IgM from the blood.

  1. Plasmapheresis (plasma exchange) removes unwanted substances from the blood. In macroglobulinemia, it removes or reduces the high level of IgM, and is used to quickly control the symptoms caused by blood thickening.
  2. Drug therapy may include steroids, Leukeran, Alkeran, Cytoxan, fludarabine, or rituximab.
  3. Patients who have a low number of red or white blood cells or platelets may need transfusions or antibiotics.