Whipples disease can be treated using antibiotics such as penicillin, tetracycline, sulfasalazine, and ampicillin.

  1. Antibiotic treatment for Whipple's disease includes intravenous penicillin and streptomycin followed by a course of TMP-SMX (Bactrim). The TMP-SMX course is administered by mouth and is continued for one year.
  2. Treatment may also include fluid and electrolyte replacement. Electrolytes are salts and other substances in body fluid that the heart and brain need to function properly.
  3. Extra iron, folate, vitamin D, calcium, and magnesium may also be given to help compensate for the vitamins and minerals the body cannot absorb on its own.