Whipples disease can be treated using antibiotics such as penicillin, tetracycline, sulfasalazine, and ampicillin.
- Antibiotic treatment for Whipple's disease includes intravenous penicillin and streptomycin followed by a course of TMP-SMX (Bactrim). The TMP-SMX course is administered by mouth and is continued for one year.
- Treatment may also include fluid and electrolyte replacement. Electrolytes are salts and other substances in body fluid that the heart and brain need to function properly.
- Extra iron, folate, vitamin D, calcium, and magnesium may also be given to help compensate for the vitamins and minerals the body cannot absorb on its own.