No team as a #16 seed has ever defeated a #1 seed since the field was expanded to 64 or more teams, though on five occasions, a #16 seed has come within 4 or fewer points of winning:

  1. Murray State lost to Michigan State by 4 points in 1990 (75-71). It was the only #16 team to ever take a game into overtime.
  2. East Tennessee State lost to Oklahoma in 1989 (1 point, 72–71)
  3. Princeton lost to Georgetown in 1989 (1 point, 50–49)
  4. Western Carolina lost to Purdue in 1996 (2 points, 73–71)
  5. Fairleigh Dickinson lost to Michigan in 1985 (4 points, 59-55)
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