| | Crowley (2009) (pre-production) .... Dr. William Canfield |
| | Crossing Over (2008) .... Max Brogan |
| | Indiana Jones and the Kingdom of the Crystal Skull (2008) .... Indiana Jones |
| | Firewall (2006) .... Jack Stanfield |
| | Water to Wine (2004) (V) (as Jethro the Bus Driver) .... Jethro the Bus Driver |
| | Hollywood Homicide (2003) .... Sgt. Joe Gavilan |
| | K-19: The Widowmaker (2002) .... Alexei Vostrikov |
| | What Lies Beneath (2000) .... Dr. Norman Spencer |
| | Random Hearts (1999) .... Dutch Van Den Broeck |
| | Six Days Seven Nights (1998) .... Quinn Harris |
| | Air Force One (1997) .... President James Marshall |
| | The Devil's Own (1997) .... Tom O'Meara |
| | Sabrina (1995) .... Linus Larrabee |
| | Clear and Present Danger (1994) .... Jack Ryan |
| | The Fugitive (1993) .... Dr. Richard David Kimble |
| | "The Young Indiana Jones Chronicles" .... Indiana Jones - age 50 (1 episode, 1993) |
| | Patriot Games (1992) .... Jack Ryan |
| | Regarding Henry (1991) .... Henry Turner |
| | Presumed Innocent (1990) .... Rusty Sabich |
| | Indiana Jones and the Last Crusade (1989) .... Indiana Jones |
| | Working Girl (1988) .... Jack Trainer |
| | Frantic (1988) .... Dr. Richard Walker |
| | The Mosquito Coast (1986) .... Allie Fox |
| | Witness (1985) .... Det. Capt. John Book |
| | Indiana Jones and the Temple of Doom (1984) .... Indiana Jones |
| | Star Wars: Episode VI - Return of the Jedi (1983) .... Han Solo |
| | Blade Runner (1982) .... Rick Deckard |
| | Raiders of the Lost Ark (1981) .... Indiana Jones |
| | Star Wars: Episode V - The Empire Strikes Back (1980) .... Han Solo |
| | More American Graffiti (1979) (uncredited) .... Officer Bob Falfa |
| | The Frisco Kid (1979) .... Tommy |
| | Hanover Street (1979) .... David Halloran |
| | Apocalypse Now (1979) .... Colonel Lucas |
| | The Star Wars Holiday Special (1978) (TV) .... Han Solo |
| | Force 10 from Navarone (1978) .... Lieutenant Colonel Mike Barnsby |
| | Heroes (1977) .... Ken Boyd |
| | Star Wars (1977) .... Han Solo |
| | The Possessed (1977) (TV) .... Paul Winjam |
| | Dynasty (1976) (TV) .... Mark Blackwood |
| | Judgment: The Court Martial of Lieutenant William Calley (1975) (TV) .... Frank Crowder |
| | "Petrocelli" .... Tom Brannigan (1 episode, 1974) |
| | The Conversation (1974) .... Martin Stett |
| | "Kung Fu" .... Harrison (1 episode, 1974) |
| | American Graffiti (1973) .... Bob Falfa |
| | "Gunsmoke" .... Hobey / ... (2 episodes, 1972-1973) |
| | "Dan August" .... Hewett (1 episode, 1971) |
| | The Intruders (1970) (TV) .... Carl |
| | Getting Straight (1970) .... Jake |
| | Zabriskie Point (1970) (uncredited) .... Airport Worker |
| | "Love, American Style" .... Roger Crane (segment "Love and the Former Marriage") (1 episode, 1969) |
| | "The F.B.I." .... Everett Giles / ... (2 episodes, 1969) |
| | "My Friend Tony" (1 episode, 1969) |
| | "The Mod Squad" .... Beach Patrol Cop (1 episode, 1968) |
| | Journey to Shiloh (1968) .... Willie Bill Bearden |
| | "Ironside" .... Tom Stowe (1 episode, 1967) |
| | "The Virginian" .... Cullen Tindall / ... (2 episodes, 1967) |
| | A Time for Killing (1967) (as Harrison J. Ford) .... Lt Shaffer |
| | Luv (1967) (uncredited) .... Hippy |
| | Dead Heat on a Merry-Go-Round (1966) (uncredited) .... Bellhop |