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Description and Symptoms of Wilsons disease (hepatolenticular degeneration)  
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Tags: Wilsons disease, autosomal recessive, hereditary disease, heterozygous, neurological, symptoms

Wilson’s disease (WD) is a rare inherited disorder in which excessive amounts of copper accumulate in the body.

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  • The first symptoms occur later in adulthood and most commonly include slurred speech (dysarthria), difficulty swallowing (dysphagia), and drooling.
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  • Other symptoms may include tremor of the head, arms, or legs; impaired muscle tone, and sustained muscle contractions that produce abnormal postures, twisting, and repetitive movements (dystonia); and slowness of movements (bradykinesia).
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  • Individuals may also experience clumsiness (ataxia) and loss of fine motor skills.
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  • A third of those with WD will also experience psychiatric symptoms such as an abrupt personality change, bizarre and inappropriate behavior, depression accompanied by suicidal thoughts, neurosis, or psychosis.

    Lister: BobbysWorld
    Source: Compiled by LAL Editor

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