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Description and Symptoms of Systemic sclerosis
INFORMATIVE 
Tags: systemic sclerosis, scleroderma, chronic disease, collagen symptoms
Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology. Fibrotic changes of the skin, subcutaneous tissue, and viscera; abnormalities of the microvasculature; and immune dysfunction characterize this disorder. In one of the first references to SSc in the medical literature, Addison referred to the skin changes as "keloid" in nature.
| | Raynaud phenomenon is usually the first symptom of systemic sclerosis. |
| | Patients experience episodes of vasospasm , which causes blood vessels in the fingers and toes to constrict. |
| | As less blood is reaching these extremities the skin changes colour to white and the fingers and toes may feel cold and numb. |
| | As they warm up, they go blue and then red before returning to normal again. |
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