Here are the ten deadliest diseases of all-time by total number of human deaths:

  1. Ischemic Heart Disease - 7,400,000 deaths
  2. Stroke - 6,400,000
  3. Chronic Obstructive Pulmonary Disease (COPD) - 3,100,000
  4. Lower Respiratory Infections - 3,100,000
  5. Trachea, Bronchus, Lung Cancers - 1,600,000
  6. HIV/AIDS - 1,500,000
  7. Diarrheal Diseases - 1,500,000
  8. Diabetes Mellitus - 1,500,000
  9. Hypertensive Heart Disease - 1,100,000
  10. Malaria - 1,000,000
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